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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo
- Holt, Nathalia;
- Wang, Jianbin;
- Kim, Kenneth;
- Friedman, Geoffrey;
- Wang, Xingchao;
- Taupin, Vanessa;
- Crooks, Gay M;
- Kohn, Donald B;
- Gregory, Philip D;
- Holmes, Michael C;
- Cannon, Paula M
Published Web Location
https://doi.org/10.1038/nbt.1663Abstract
Holt et al. describe an anti-HIV strategy in which human hematopoietic stem/progenitor cells are modified with zinc-finger nucleases to knock out the viral co-receptor CCR5. Transplantation of these cells into mice confers resistance to HIV, as shown by higher human T-cell counts and lower viral loads compared with animals that received unmodified cells.
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