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Genome-wide meta-analyses identifies novel taxane-induced peripheral neuropathy-associated loci.

  • Author(s): Sucheston-Campbell, Lara E
  • Clay-Gilmour, Alyssa I
  • Barlow, William E
  • Budd, G Thomas
  • Stram, Daniel O
  • Haiman, Christopher A
  • Sheng, Xin
  • Yan, Li
  • Zirpoli, Gary
  • Yao, Song
  • Jiang, Chen
  • Owzar, Kouros
  • Hershman, Dawn
  • Albain, Kathy S
  • Hayes, Daniel F
  • Moore, Halle C
  • Hobday, Timothy J
  • Stewart, James A
  • Rizvi, Abbas
  • Isaacs, Claudine
  • Salim, Muhammad
  • Gralow, Jule R
  • Hortobagyi, Gabriel N
  • Livingston, Robert B
  • Kroetz, Deanna L
  • Ambrosone, Christine B
  • et al.
Abstract

OBJECTIVE:Taxane containing chemotherapy extends survival for breast cancer patients. However, taxane-induced peripheral neuropathy (TIPN) cannot be predicted, prevented or effectively treated. Using genome-wide analyses, we sought to identify common risk variants for TIPN. PATIENTS AND METHODS:Women with high-risk breast cancer enrolled in SWOG 0221 were genotyped using the Illumina 1M chip. Genome-wide analyses were performed in relation to ≥grade 3 Common Terminology Criteria for Adverse Events (CTCAE) neuropathy in European and African Americans. Data were meta-analyzed with GW associations of CTCAE ≥grade 3 versus

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