UC San Diego

Proteins are one of the primary macromolecules that carry out the many essential functions of life. They catalyze chemical reactions, provide structural integrity, and perform biological motor functions. Proteins dynamically interact with surrounding molecules by diffusing, binding, and changing conformations, signaling their stage in biochemical processes. Interpreting these signals is key to harnessing control over protein function for beneficial purposes, such as inhibiting disease related proteins and synthesizing desired molecules including biofuels and therapeutics. This dissertation investigates the communication mechanisms of two protein classes: acyl carrier proteins (ACPs) and SARS-CoV-2 viral proteins. The methods and fundamental properties uncovered herein are expected to be applicable to a broad range of protein systems.