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Enantioselective Intramolecular C–H Insertion Reactions of Donor–Donor Metal Carbenoids

Published Web Location

https://doi.org/10.1021/ja508586t
Abstract

The first asymmetric insertion reactions of donor-donor carbenoids, i.e., those with no pendant electron-withdrawing groups, are reported. This process enables the synthesis of densely substituted benzodihydrofurans with high levels of enantio- and diastereoselectivity. Preliminary results show similar efficiency in the preparation of indanes. This new method is used in the first enantioselective synthesis of an oligoresveratrol natural product (E-δ-viniferin).

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