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Immune Response Signaling: Combinatorial and Dynamic Control
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https://doi.org/10.1016/j.it.2016.07.003Abstract
Macrophages mount complex responses to pathogens. Although several key signaling pathways have been identified, it remains unclear how they work together to provide specificity. In a recent paper, Gottschalk et al. report that differential dose-response behaviors of the NFκB and MAPK pathways allow dose-specific gene expression programs.
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