Immune Response Signaling: Combinatorial and Dynamic Control.
- Author(s): Hoffmann, Alexander
- et al.
Published Web Locationhttps://doi.org/10.1016/j.it.2016.07.003
Macrophages mount complex responses to pathogens. Although several key signaling pathways have been identified, it remains unclear how they work together to provide specificity. In a recent paper, Gottschalk et al. report that differential dose-response behaviors of the NFκB and MAPK pathways allow dose-specific gene expression programs.