School of Medicine

The purpose of this project is to review approaches to improve the medical treatment of breast cancer. This review will focus on the current literature that addresses (1) the current strategy for the sequence of adjuvant chemohormonal therapy in non-metastatic hormone receptor positive (HR+), human epidermal growth factor 2 (HER2) negative breast cancer, (2) progesterone therapy in the neoadjuvant setting, (3) high dose estrogens as salvage therapy in hormone therapy-refractory patients, (4) the concurrent use of mTOR or CDK4/6 inhibitors with hormone therapy, and (5) the use of efflux pump reversal agents in chemotherapy-refractory patients. Based on the presented evidence, discussions will focus on limitations of the current data and the role of novel therapies within the framework of current standard of care.