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Endogenous antigen tunes the responsiveness of naive B cells but not T cells

  • Author(s): Zikherman, Julie
  • Weiss, Arthur
  • Parameswaran, R
  • et al.

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In humans, up to 75% of newly generated B cells and about 30% of mature B cells show some degree of autoreactivity. Yet, how B cells establish and maintain tolerance in the face of autoantigen exposure during and after development is not certain. Studies o

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