Endogenous antigen tunes the responsiveness of naive B cells but not T cells
- Author(s): Zikherman, Julie
- Weiss, Arthur
- Parameswaran, R
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3438375?pdf=render
In humans, up to 75% of newly generated B cells and about 30% of mature B cells show some degree of autoreactivity. Yet, how B cells establish and maintain tolerance in the face of autoantigen exposure during and after development is not certain. Studies o