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STIM1, PKC-δ and RasGRP set a threshold for proapoptotic Erk signaling during B cell development
- Limnander, Andre;
- Depeille, Philippe;
- Freedman, Tanya S;
- Liou, Jen;
- Leitges, Michael;
- Kurosaki, Tomohiro;
- Roose, Jeroen P;
- Weiss, Arthur
Published Web Location
https://doi.org/10.1038/ni.2016Abstract
Developing B cells show enhanced sensitivity to negatively selecting signals. Weiss and colleagues show that calcium signals arising from activation of the calcium sensor STIM1 lead to activation of Erk and apoptosis via a protein kinase C-δ and the guanine nucleotide-exchange factor RasGRP1-dependent pathway in transitional self-reactive B cells.
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