Particle deposition and clearance as a test of toxic effect
- Author(s): Phalen, RF;
- Hallford, JD;
- Kenoyer, JL
- et al.
The field of inhalation toxicology is currently in an intriguing active phase characterized by two features: (1) compilation, description and quantitation of effects other than mortality that include physiological, morphological and biochemical parameters, and (2) development of an understanding of biologic responses in terms of the physical and chemical properties of inhaled materials. Further development in both of these areas seems necessary for inhalation toxicology to become a predictive discipline as opposed to merely a descriptive one. The phenomena associated with deposition and clearance of inhaled particles have recently been recognized as important aspects of the defensive mechanisms of the lung. The purpose of this paper is to justify the use of deposition and clearance tests in the inhalation toxicology laboratory. AMRL-TR-75-125