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High resolution structure and double electron-electron resonance of the zebrafish voltage-dependent anion channel 2 reveal an oligomeric population

  • Author(s): Schredelseker, J
  • Paz, A
  • López, CJ
  • Altenbach, C
  • Leung, CS
  • Drexler, MK
  • Chen, JN
  • Hubbell, WL
  • Abramson, J
  • et al.
Abstract

Background: Biochemical characterization of voltage-dependent anion channel 2 (VDAC2) is limited due to an inability to obtain functional protein. Results: The crystal structure ofVDAC2suggests a dimer interface that is confirmed by double electron-electron resonance and cross-linking. Conclusion: zfVDAC2 has a fractional dimeric population. Significance: VDAC isoforms are structurally similar, but this study has identified a number of hot spots that require further exploration. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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