UC Santa Barbara

The neural logic underlying the conversion of non-stationary (dynamic) olfactory inputs into odor-search behaviors has been difficult to crack due to the distributed nature of the olfactory code - food odors typically co-activate multiple olfactory sensory neurons. In the Drosophila larva, the activity of a single olfactory sensory neuron is sufficient to direct accurate reorientation maneuvers in odor gradients (chemotaxis). In this reduced sensory system, a descending pathway essential for larval chemotaxis has been delineated from the peripheral olfactory system down to the premotor system. Here, I review how anatomical and functional inspections of this pathway have advanced our understanding of the neural mechanisms that convert behaviorally relevant sensory signals into orientation responses.