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Open Access Publications from the University of California

Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry

  • Author(s): Abel, GR
  • Cao, BH
  • Hein, JE
  • Ye, T
  • et al.

We present a novel method that covalently and sequence-specifically attaches long DNA molecules to a surface that is compatible with high-resolution atomic force microscopy (AFM) imaging. Surfaces prepared with this approach are ideally suited for performing biophysical experiments on single DNA molecules. This journal is © the Partner Organisations 2014.

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