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Open Access Publications from the University of California

Covalent, sequence-specific attachment of long DNA molecules to a surface using DNA-templated click chemistry.

  • Author(s): Abel, Gary R
  • Cao, Blessing Huynh
  • Hein, Jason E
  • Ye, Tao
  • et al.
Abstract

We present a novel method that covalently and sequence-specifically attaches long DNA molecules to a surface that is compatible with high-resolution atomic force microscopy (AFM) imaging. Surfaces prepared with this approach are ideally suited for performing biophysical experiments on single DNA molecules.

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