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TSPAN33 is a novel marker of activated and malignant B cells
- Luu, Van Phi;
- Hevezi, Peter;
- Vences-Catalan, Felipe;
- Maravillas-Montero, José Luis;
- White, Clayton Alexander;
- Casali, Paolo;
- Llorente, Luis;
- Jakez-Ocampo, Juan;
- Lima, Guadalupe;
- Vilches-Cisneros, Natalia;
- Flores-Gutiérrez, Juan Pablo;
- Santos-Argumedo, Leopoldo;
- Zlotnik, Albert
Published Web Location
https://doi.org/10.1016/j.clim.2013.08.005Abstract
We have identified Tspan33 as a gene encoding a transmembrane protein exhibiting a restricted expression pattern including expression in activated B cells. TSPAN33 is a member of the tetraspanin family. TSPAN33 is not expressed in resting B cells, but is strongly induced in primary human B cells following activation. Human 2E2 cells, a Burkitt's lymphoma-derived B cell model of activation and differentiation, also upregulate TSPAN33 upon activation. TSPAN33 is expressed in several lymphomas including Hodgkin's and Diffuse large B cell lymphoma. TSPAN33 is also expressed in some autoimmune diseases where B cells participate in the pathology, including rheumatoid arthritis patients, systemic lupus erythematosus (SLE), and in spleen B cells from MRL/Fas(lpr/lpr) mice (a mouse model of SLE). We conclude that TSPAN33 may be used as a diagnostic biomarker or as a target for therapeutic antibodies for treatment of certain B cell lymphomas or autoimmune diseases.
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