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HIV-infected individuals with co-occurring bipolar disorder evidence poor antiretroviral and psychiatric medication adherence

  • Author(s): Moore, DJ
  • Posada, C
  • Parikh, M
  • Arce, M
  • Vaida, F
  • Riggs, PK
  • Gouaux, B
  • Ellis, RJ
  • Letendre, SL
  • Grant, I
  • Atkinson, JH
  • et al.

Published Web Location

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3351543/
No data is associated with this publication.
Abstract

The contribution of bipolar disorder (BD), a prevalent serious mental illness characterized by impulsivity and mood instability, to antiretroviral (ART) and psychiatric medication adherence among HIV-infected (HIV+) individuals is unknown. We examined medication adherence among 44 HIV+/BD+ persons as compared to 33 demographically- and medically-comparable HIV+/BD-persons. Classification of adherent (≥90%) or nonadherent (<90%) based on proportion of correctly taken doses over 30 days was determined using electronic medication monitoring devices. HIV+/BD+ persons were significantly less likely to be ART adherent (47.7%) as compared to HIV+/BD- (90.9%) persons. Within the HIV+/BD+ group, mean psychiatric medication adherence was significantly worse than ART medication adherence, although there was a significant correlation between ART and psychiatric adherence levels. Importantly, 30-day ART adherence was associated with plasma virologic response among HIV+/BD+ individuals. Given the high overlap of HIV and BD, and the observed medication adherence difficulties for these persons, specialized adherence improvement interventions are needed. © Springer Science+Business Media, LLC 2011.

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