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Open Access Publications from the University of California

Synthesis of highly substituted adamantanones from bicyclo[3.3.1]nonanes.

  • Author(s): Jung, Michael E
  • Lee, Gloria S
  • et al.

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Trifluoromethanesulfonic acid and other electrophiles promote formation of the adamantanone core from the readily accessible 1,5-dimethyl-3,7-dimethylenebicyclo[3.3.1]nonan-9-one 2. Because adamantyl cation 3 can be trapped by a range of nucleophiles, including aromatic and heteroaromatic rings, alcohol, nitriles, and halides, access to a wide variety of functionality at the newly formed tertiary position is provided.

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