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Monocyte Protection of Dental Pulp Stem Cells from Natural Killer Cell Mediated Cytotoxicity

  • Author(s): Arasteh, Hobie H.
  • Advisor(s): Jewett, Anahid
  • et al.
Abstract

The aim of this study is to understand the role of immune regulators such as Natural Killer Cells and Monocytes with Dental Pulp Stem Cells (DPSCs). In this study we will demonstrate that DPSCs are very sensitive to Natural Killer cells attack and will undergo cell-mediated lysis. However Monocytes are able to increase the survival of DPSCs and rescue DPSCs from Natural Killer cells cell-mediated lysis. We further analyze the different subpopulation of Monocytes CD16- and CD16+ cell surface receptors to provide an immunotherapeutic tool for tissue regeneration and repair of DPSCs in an event of a stress to a cell.

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