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Symptomology following mRNA vaccination against SARS-CoV-2
- Ebinger, Joseph E;
- Lan, Roy;
- Sun, Nancy;
- Wu, Min;
- Joung, Sandy;
- Botwin, Gregory J;
- Botting, Patrick;
- Al-Amili, Daniah;
- Aronow, Harriet;
- Beekley, James;
- Coleman, Bernice;
- Contreras, Sandra;
- Cozen, Wendy;
- Davis, Jennifer;
- Debbas, Philip;
- Diaz, Jacqueline;
- Driver, Matthew;
- Fert-Bober, Justyna;
- Gu, Quanquan;
- Heath, Mallory;
- Herrera, Ergueen;
- Hoang, Amy;
- Hussain, Shehnaz K;
- Huynh, Carissa;
- Kim, Linda;
- Kittleson, Michelle;
- Liu, Yunxian;
- Lloyd, John;
- Luong, Eric;
- Malladi, Bhavya;
- Merchant, Akil;
- Merin, Noah;
- Mujukian, Angela;
- Nguyen, Nathalie;
- Nguyen, Trevor-Trung;
- Pozdnyakova, Valeriya;
- Rashid, Mohamad;
- Raedschelders, Koen;
- Reckamp, Karen L;
- Rhoades, Kylie;
- Sternbach, Sarah;
- Vallejo, Rocío;
- White, Shane;
- Tompkins, Rose;
- Wong, Melissa;
- Arditi, Moshe;
- Figueiredo, Jane C;
- Van Eyk, Jennifer E;
- Miles, Peggy B;
- Chavira, Cynthia;
- Shane, Rita;
- Sobhani, Kimia;
- Melmed, Gil Y;
- McGovern, Dermot PB;
- Braun, Jonathan G;
- Cheng, Susan;
- Minissian, Margo B
- et al.
Published Web Location
https://doi.org/10.1016/j.ypmed.2021.106860Abstract
Despite demonstrated efficacy of vaccines against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the causative agent of coronavirus disease-2019 (COVID-19), widespread hesitancy to vaccination persists. Improved knowledge regarding frequency, severity, and duration of vaccine-associated symptoms may help reduce hesitancy. In this prospective observational study, we studied 1032 healthcare workers who received both doses of the Pfizer-BioNTech SARS-CoV-2 mRNA vaccine and completed post-vaccine symptom surveys both after dose 1 and after dose 2. We defined appreciable post-vaccine symptoms as those of at least moderate severity and lasting at least 2 days. We found that symptoms were more frequent following the second vaccine dose than the first (74% vs. 60%, P < 0.001), with >80% of all symptoms resolving within 2 days. The most common symptom was injection site pain, followed by fatigue and malaise. Overall, 20% of participants experienced appreciable symptoms after dose 1 and 30% after dose 2. In multivariable analyses, female sex was associated with greater odds of appreciable symptoms after both dose 1 (OR, 95% CI 1.73, 1.19-2.51) and dose 2 (1.76, 1.28-2.42). Prior COVID-19 was also associated with appreciable symptoms following dose 1, while younger age and history of hypertension were associated with appreciable symptoms after dose 2. We conclude that most post-vaccine symptoms are reportedly mild and last <2 days. Appreciable post-vaccine symptoms are associated with female sex, prior COVID-19, younger age, and hypertension. This information can aid clinicians in advising patients on the safety and expected symptomatology associated with vaccination.
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