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Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

  • Author(s): Adema, Coen M;
  • Hillier, LaDeana W;
  • Jones, Catherine S;
  • Loker, Eric S;
  • Knight, Matty;
  • Minx, Patrick;
  • Oliveira, Guilherme;
  • Raghavan, Nithya;
  • Shedlock, Andrew;
  • do Amaral, Laurence Rodrigues;
  • Arican-Goktas, Halime D;
  • Assis, Juliana G;
  • Baba, Elio Hideo;
  • Baron, Olga L;
  • Bayne, Christopher J;
  • Bickham-Wright, Utibe;
  • Biggar, Kyle K;
  • Blouin, Michael;
  • Bonning, Bryony C;
  • Botka, Chris;
  • Bridger, Joanna M;
  • Buckley, Katherine M;
  • Buddenborg, Sarah K;
  • Lima Caldeira, Roberta;
  • Carleton, Julia;
  • Carvalho, Omar S;
  • Castillo, Maria G;
  • Chalmers, Iain W;
  • Christensens, Mikkel;
  • Clifton, Sandra;
  • Cosseau, Celine;
  • Coustau, Christine;
  • Cripps, Richard M;
  • Cuesta-Astroz, Yesid;
  • Cummins, Scott F;
  • di Stephano, Leon;
  • Dinguirard, Nathalie;
  • Duval, David;
  • Emrich, Scott;
  • Feschotte, Cédric;
  • Feyereisen, Rene;
  • FitzGerald, Peter;
  • Fronick, Catrina;
  • Fulton, Lucinda;
  • Galinier, Richard;
  • Gava, Sandra G;
  • Geusz, Michael;
  • Geyer, Kathrin K;
  • Giraldo-Calderón, Gloria I;
  • de Souza Gomes, Matheus;
  • Gordy, Michelle A;
  • Gourbal, Benjamin;
  • Grunau, Christoph;
  • Hanington, Patrick C;
  • Hoffmann, Karl F;
  • Hughes, Daniel;
  • Humphries, Judith;
  • Jackson, Daniel J;
  • Jannotti-Passos, Liana K;
  • de Jesus Jeremias, Wander;
  • Jobling, Susan;
  • Kamel, Bishoy;
  • Kapusta, Aurélie;
  • Kaur, Satwant;
  • Koene, Joris M;
  • Kohn, Andrea B;
  • Lawson, Dan;
  • Lawton, Scott P;
  • Liang, Di;
  • Limpanont, Yanin;
  • Liu, Sijun;
  • Lockyer, Anne E;
  • Lovato, TyAnna L;
  • Ludolf, Fernanda;
  • Magrini, Vince;
  • McManus, Donald P;
  • Medina, Monica;
  • Misra, Milind;
  • Mitta, Guillaume;
  • Mkoji, Gerald M;
  • Montague, Michael J;
  • Montelongo, Cesar;
  • Moroz, Leonid L;
  • Munoz-Torres, Monica C;
  • Niazi, Umar;
  • Noble, Leslie R;
  • Oliveira, Francislon S;
  • Pais, Fabiano S;
  • Papenfuss, Anthony T;
  • Peace, Rob;
  • Pena, Janeth J;
  • Pila, Emmanuel A;
  • Quelais, Titouan;
  • Raney, Brian J;
  • Rast, Jonathan P;
  • Rollinson, David;
  • Rosse, Izinara C;
  • Rotgans, Bronwyn;
  • Routledge, Edwin J;
  • Ryan, Kathryn M;
  • Scholte, Larissa LS;
  • Storey, Kenneth B;
  • Swain, Martin;
  • Tennessen, Jacob A;
  • Tomlinson, Chad;
  • Trujillo, Damian L;
  • Volpi, Emanuela V;
  • Walker, Anthony J;
  • Wang, Tianfang;
  • Wannaporn, Ittiprasert;
  • Warren, Wesley C;
  • Wu, Xiao-Jun;
  • Yoshino, Timothy P;
  • Yusuf, Mohammed;
  • Zhang, Si-Ming;
  • Zhao, Min;
  • Wilson, Richard K
  • et al.
Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

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