- Main
Whole genome analysis of a schistosomiasis-transmitting freshwater snail.
- Adema, Coen M;
- Hillier, LaDeana W;
- Jones, Catherine S;
- Loker, Eric S;
- Knight, Matty;
- Minx, Patrick;
- Oliveira, Guilherme;
- Raghavan, Nithya;
- Shedlock, Andrew;
- do Amaral, Laurence Rodrigues;
- Arican-Goktas, Halime D;
- Assis, Juliana G;
- Baba, Elio Hideo;
- Baron, Olga L;
- Bayne, Christopher J;
- Bickham-Wright, Utibe;
- Biggar, Kyle K;
- Blouin, Michael;
- Bonning, Bryony C;
- Botka, Chris;
- Bridger, Joanna M;
- Buckley, Katherine M;
- Buddenborg, Sarah K;
- Lima Caldeira, Roberta;
- Carleton, Julia;
- Carvalho, Omar S;
- Castillo, Maria G;
- Chalmers, Iain W;
- Christensens, Mikkel;
- Clifton, Sandra;
- Cosseau, Celine;
- Coustau, Christine;
- Cripps, Richard M;
- Cuesta-Astroz, Yesid;
- Cummins, Scott F;
- di Stephano, Leon;
- Dinguirard, Nathalie;
- Duval, David;
- Emrich, Scott;
- Feschotte, Cédric;
- Feyereisen, Rene;
- FitzGerald, Peter;
- Fronick, Catrina;
- Fulton, Lucinda;
- Galinier, Richard;
- Gava, Sandra G;
- Geusz, Michael;
- Geyer, Kathrin K;
- Giraldo-Calderón, Gloria I;
- de Souza Gomes, Matheus;
- Gordy, Michelle A;
- Gourbal, Benjamin;
- Grunau, Christoph;
- Hanington, Patrick C;
- Hoffmann, Karl F;
- Hughes, Daniel;
- Humphries, Judith;
- Jackson, Daniel J;
- Jannotti-Passos, Liana K;
- de Jesus Jeremias, Wander;
- Jobling, Susan;
- Kamel, Bishoy;
- Kapusta, Aurélie;
- Kaur, Satwant;
- Koene, Joris M;
- Kohn, Andrea B;
- Lawson, Dan;
- Lawton, Scott P;
- Liang, Di;
- Limpanont, Yanin;
- Liu, Sijun;
- Lockyer, Anne E;
- Lovato, TyAnna L;
- Ludolf, Fernanda;
- Magrini, Vince;
- McManus, Donald P;
- Medina, Monica;
- Misra, Milind;
- Mitta, Guillaume;
- Mkoji, Gerald M;
- Montague, Michael J;
- Montelongo, Cesar;
- Moroz, Leonid L;
- Munoz-Torres, Monica C;
- Niazi, Umar;
- Noble, Leslie R;
- Oliveira, Francislon S;
- Pais, Fabiano S;
- Papenfuss, Anthony T;
- Peace, Rob;
- Pena, Janeth J;
- Pila, Emmanuel A;
- Quelais, Titouan;
- Raney, Brian J;
- Rast, Jonathan P;
- Rollinson, David;
- Rosse, Izinara C;
- Rotgans, Bronwyn;
- Routledge, Edwin J;
- Ryan, Kathryn M;
- Scholte, Larissa LS;
- Storey, Kenneth B;
- Swain, Martin;
- Tennessen, Jacob A;
- Tomlinson, Chad;
- Trujillo, Damian L;
- Volpi, Emanuela V;
- Walker, Anthony J;
- Wang, Tianfang;
- Wannaporn, Ittiprasert;
- Warren, Wesley C;
- Wu, Xiao-Jun;
- Yoshino, Timothy P;
- Yusuf, Mohammed;
- Zhang, Si-Ming;
- Zhao, Min;
- Wilson, Richard K
- et al.
Published Web Location
https://doi.org/10.1038/ncomms15451Abstract
Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.
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