Skip to main content
eScholarship
Open Access Publications from the University of California

Whole genome analysis of a schistosomiasis-transmitting freshwater snail.

  • Author(s): Adema, Coen M
  • Hillier, LaDeana W
  • Jones, Catherine S
  • Loker, Eric S
  • Knight, Matty
  • Minx, Patrick
  • Oliveira, Guilherme
  • Raghavan, Nithya
  • Shedlock, Andrew
  • do Amaral, Laurence Rodrigues
  • Arican-Goktas, Halime D
  • Assis, Juliana G
  • Baba, Elio Hideo
  • Baron, Olga L
  • Bayne, Christopher J
  • Bickham-Wright, Utibe
  • Biggar, Kyle K
  • Blouin, Michael
  • Bonning, Bryony C
  • Botka, Chris
  • Bridger, Joanna M
  • Buckley, Katherine M
  • Buddenborg, Sarah K
  • Lima Caldeira, Roberta
  • Carleton, Julia
  • Carvalho, Omar S
  • Castillo, Maria G
  • Chalmers, Iain W
  • Christensens, Mikkel
  • Clifton, Sandra
  • Cosseau, Celine
  • Coustau, Christine
  • Cripps, Richard M
  • Cuesta-Astroz, Yesid
  • Cummins, Scott F
  • di Stephano, Leon
  • Dinguirard, Nathalie
  • Duval, David
  • Emrich, Scott
  • Feschotte, Cédric
  • Feyereisen, Rene
  • FitzGerald, Peter
  • Fronick, Catrina
  • Fulton, Lucinda
  • Galinier, Richard
  • Gava, Sandra G
  • Geusz, Michael
  • Geyer, Kathrin K
  • Giraldo-Calderón, Gloria I
  • de Souza Gomes, Matheus
  • Gordy, Michelle A
  • Gourbal, Benjamin
  • Grunau, Christoph
  • Hanington, Patrick C
  • Hoffmann, Karl F
  • Hughes, Daniel
  • Humphries, Judith
  • Jackson, Daniel J
  • Jannotti-Passos, Liana K
  • de Jesus Jeremias, Wander
  • Jobling, Susan
  • Kamel, Bishoy
  • Kapusta, Aurélie
  • Kaur, Satwant
  • Koene, Joris M
  • Kohn, Andrea B
  • Lawson, Dan
  • Lawton, Scott P
  • Liang, Di
  • Limpanont, Yanin
  • Liu, Sijun
  • Lockyer, Anne E
  • Lovato, TyAnna L
  • Ludolf, Fernanda
  • Magrini, Vince
  • McManus, Donald P
  • Medina, Monica
  • Misra, Milind
  • Mitta, Guillaume
  • Mkoji, Gerald M
  • Montague, Michael J
  • Montelongo, Cesar
  • Moroz, Leonid L
  • Munoz-Torres, Monica C
  • Niazi, Umar
  • Noble, Leslie R
  • Oliveira, Francislon S
  • Pais, Fabiano S
  • Papenfuss, Anthony T
  • Peace, Rob
  • Pena, Janeth J
  • Pila, Emmanuel A
  • Quelais, Titouan
  • Raney, Brian J
  • Rast, Jonathan P
  • Rollinson, David
  • Rosse, Izinara C
  • Rotgans, Bronwyn
  • Routledge, Edwin J
  • Ryan, Kathryn M
  • Scholte, Larissa LS
  • Storey, Kenneth B
  • Swain, Martin
  • Tennessen, Jacob A
  • Tomlinson, Chad
  • Trujillo, Damian L
  • Volpi, Emanuela V
  • Walker, Anthony J
  • Wang, Tianfang
  • Wannaporn, Ittiprasert
  • Warren, Wesley C
  • Wu, Xiao-Jun
  • Yoshino, Timothy P
  • Yusuf, Mohammed
  • Zhang, Si-Ming
  • Zhao, Min
  • Wilson, Richard K
  • et al.
Abstract

Biomphalaria snails are instrumental in transmission of the human blood fluke Schistosoma mansoni. With the World Health Organization's goal to eliminate schistosomiasis as a global health problem by 2025, there is now renewed emphasis on snail control. Here, we characterize the genome of Biomphalaria glabrata, a lophotrochozoan protostome, and provide timely and important information on snail biology. We describe aspects of phero-perception, stress responses, immune function and regulation of gene expression that support the persistence of B. glabrata in the field and may define this species as a suitable snail host for S. mansoni. We identify several potential targets for developing novel control measures aimed at reducing snail-mediated transmission of schistosomiasis.

Main Content
Current View