Skip to main content
eScholarship
Open Access Publications from the University of California

Structural genomics is the largest contributor of novel structural leverage.

  • Author(s): Nair, Rajesh
  • Liu, Jinfeng
  • Soong, Ta-Tsen
  • Acton, Thomas B
  • Everett, John K
  • Kouranov, Andrei
  • Fiser, Andras
  • Godzik, Adam
  • Jaroszewski, Lukasz
  • Orengo, Christine
  • Montelione, Gaetano T
  • Rost, Burkhard
  • et al.
Abstract

The Protein Structural Initiative (PSI) at the US National Institutes of Health (NIH) is funding four large-scale centers for structural genomics (SG). These centers systematically target many large families without structural coverage, as well as very large families with inadequate structural coverage. Here, we report a few simple metrics that demonstrate how successfully these efforts optimize structural coverage: while the PSI-2 (2005-now) contributed more than 8% of all structures deposited into the PDB, it contributed over 20% of all novel structures (i.e. structures for protein sequences with no structural representative in the PDB on the date of deposition). The structural coverage of the protein universe represented by today's UniProt (v12.8) has increased linearly from 1992 to 2008; structural genomics has contributed significantly to the maintenance of this growth rate. Success in increasing novel leverage (defined in Liu et al. in Nat Biotechnol 25:849-851, 2007) has resulted from systematic targeting of large families. PSI's per structure contribution to novel leverage was over 4-fold higher than that for non-PSI structural biology efforts during the past 8 years. If the success of the PSI continues, it may just take another approximately15 years to cover most sequences in the current UniProt database.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View