Skip to main content
eScholarship
Open Access Publications from the University of California

Media ion composition controls regulatory and virulence response of Salmonella in spaceflight

  • Author(s): Wilson, JW
  • Ott, CM
  • Quick, L
  • Davis, R
  • zu Bentrup, KH
  • Crabbé, A
  • Richter, E
  • Sarker, S
  • Barrila, J
  • Porwollik, S
  • Cheng, P
  • McClelland, M
  • Tsaprailis, G
  • Radabaugh, T
  • Hunt, A
  • Shah, M
  • Nelman-Gonzalez, M
  • Hing, S
  • Parra, M
  • Dumars, P
  • Norwood, K
  • Bober, R
  • Devich, J
  • Ruggles, A
  • CdeBaca, A
  • Narayan, S
  • Benjamin, J
  • Goulart, C
  • Rupert, M
  • Catella, L
  • Schurr, MJ
  • Buchanan, K
  • Morici, L
  • McCracken, J
  • Porter, MD
  • Pierson, DL
  • Smith, SM
  • Mergeay, M
  • Leys, N
  • Stefanyshyn-Piper, HM
  • Gorie, D
  • Nickerson, CA
  • et al.
Abstract

The spaceflight environment is relevant to conditions encountered by pathogens during the course of infection and induces novel changes in microbial pathogenesis not observed using conventional methods. It is unclear how microbial cells sense spaceflight-associated changes to their growth environment and orchestrate corresponding changes in molecular and physiological phenotypes relevant to the infection process. Here we report that spaceflight-induced increases in Salmonella virulence are regulated by media ion composition, and that phosphate ion is sufficient to alter related pathogenesis responses in a spaceflight analogue model. Using whole genome microarray and proteomic analyses from two independent. Space Shuttle missions, we identified evolutionary conserved molecular pathways in Salmonella that respond to spaceflight under all media compositions tested. Identification of conserved regulatory paradigms opens new avenues to control microbial responses during the infection process and holds promise to provide an improved understanding of human health and disease on Earth.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View