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Extracellular activation of Wnt signaling through epigenetic dysregulation of Wnt inhibitory factor-1 (Wif-1) is associated with pathogenesis of adrenocortical tumor

  • Author(s): Dahiya, Rajvir
  • Mitsui, Y
  • Yasumoto, H
  • Nagami, T
  • Hiraki, M
  • Arichi, N
  • Ishikawa, N
  • Araki, A
  • Maruyama, R
  • Tanaka, Y
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4039156?pdf=render
No data is associated with this publication.
Abstract

Wnt/ß-catenin signaling is considered to be an essential regulator of adrenocortical oncogenesis. Wnt inhibitory factor-1 (Wif-1), an extracellular regulator of Wnt signaling, is frequently down-regulated by hypermethylation of the promoter CpG. We investi

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