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Supramolecular Nanosubstrate‐Mediated Delivery for Reprogramming and Transdifferentiation of Mammalian Cells
- Hou, Shuang;
- Choi, Jin-sil;
- Chen, Kuan-Ju;
- Zhang, Yang;
- Peng, Jinliang;
- Garcia, Mitch A;
- Yu, Jue-Hua;
- Thakore-Shah, Kaushali;
- Ro, Tracy;
- Chen, Jie-Fu;
- Peyda, Parham;
- Fan, Guoping;
- Pyle, April D;
- Wang, Hao;
- Tseng, Hsian-Rong
Published Web Location
https://doi.org/10.1002/smll.201402602Abstract
Supramolecular nanosubstrate-mediated delivery (SNSMD) leverages the power of molecular self-assembly and a nanostructured substrate platform for the low toxicity, highly efficient co-delivery of biological factors encapsulated in a nanovector. Human fibroblasts are successfully reprogrammed into induced pluripotent stems and transdifferentiated into induced neuronal-like cells.
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