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The associations of anthropometric, behavioural and sociodemographic factors with circulating concentrations of IGF-I, IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 in a pooled analysis of 16,024 men from 22 studies.

  • Author(s): Watts, Eleanor L
  • Perez-Cornago, Aurora
  • Appleby, Paul N
  • Albanes, Demetrius
  • Ardanaz, Eva
  • Black, Amanda
  • Bueno-de-Mesquita, H Bas
  • Chan, June M
  • Chen, Chu
  • Chubb, SA Paul
  • Cook, Michael B
  • Deschasaux, Mélanie
  • Donovan, Jenny L
  • English, Dallas R
  • Flicker, Leon
  • Freedman, Neal D
  • Galan, Pilar
  • Giles, Graham G
  • Giovannucci, Edward L
  • Gunter, Marc J
  • Habel, Laurel A
  • Häggström, Christel
  • Haiman, Christopher
  • Hamdy, Freddie C
  • Hercberg, Serge
  • Holly, Jeff M
  • Huang, Jiaqi
  • Huang, Wen-Yi
  • Johansson, Mattias
  • Kaaks, Rudolf
  • Kubo, Tatsuhiko
  • Lane, J Athene
  • Layne, Tracy M
  • Le Marchand, Loic
  • Martin, Richard M
  • Metter, E Jeffrey
  • Mikami, Kazuya
  • Milne, Roger L
  • Morris, Howard A
  • Mucci, Lorelei A
  • Neal, David E
  • Neuhouser, Marian L
  • Oliver, Steven E
  • Overvad, Kim
  • Ozasa, Kotaro
  • Pala, Valeria
  • Pernar, Claire H
  • Pollak, Michael
  • Rowlands, Mari-Anne
  • Schaefer, Catherine A
  • Schenk, Jeannette M
  • Stattin, Pär
  • Tamakoshi, Akiko
  • Thysell, Elin
  • Touvier, Mathilde
  • Trichopoulou, Antonia
  • Tsilidis, Konstantinos K
  • Van Den Eeden, Stephen K
  • Weinstein, Stephanie J
  • Wilkens, Lynne
  • Yeap, Bu B
  • Key, Timothy J
  • Allen, Naomi E
  • Travis, Ruth C
  • et al.

Published Web Location

https://doi.org/10.1002/ijc.32276
Abstract

Insulin-like growth factors (IGFs) and insulin-like growth factor binding proteins (IGFBPs) have been implicated in the aetiology of several cancers. To better understand whether anthropometric, behavioural and sociodemographic factors may play a role in cancer risk via IGF signalling, we examined the cross-sectional associations of these exposures with circulating concentrations of IGFs (IGF-I and IGF-II) and IGFBPs (IGFBP-1, IGFBP-2 and IGFBP-3). The Endogenous Hormones, Nutritional Biomarkers and Prostate Cancer Collaborative Group dataset includes individual participant data from 16,024 male controls (i.e. without prostate cancer) aged 22-89 years from 22 prospective studies. Geometric means of protein concentrations were estimated using analysis of variance, adjusted for relevant covariates. Older age was associated with higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGF-I, IGF-II and IGFBP-3. Higher body mass index was associated with lower concentrations of IGFBP-1 and IGFBP-2. Taller height was associated with higher concentrations of IGF-I and IGFBP-3 and lower concentrations of IGFBP-1. Smokers had higher concentrations of IGFBP-1 and IGFBP-2 and lower concentrations of IGFBP-3 than nonsmokers. Higher alcohol consumption was associated with higher concentrations of IGF-II and lower concentrations of IGF-I and IGFBP-2. African Americans had lower concentrations of IGF-II, IGFBP-1, IGFBP-2 and IGFBP-3 and Hispanics had lower IGF-I, IGF-II and IGFBP-3 than non-Hispanic whites. These findings indicate that a range of anthropometric, behavioural and sociodemographic factors are associated with circulating concentrations of IGFs and IGFBPs in men, which will lead to a greater understanding of the mechanisms through which these factors influence cancer risk.

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