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Inflammation-induced IgA+ cells dismantle anti-liver cancer immunity
- Shalapour, Shabnam;
- Lin, Xue-Jia;
- Bastian, Ingmar N;
- Brain, John;
- Burt, Alastair D;
- Aksenov, Alexander A;
- Vrbanac, Alison F;
- Li, Weihua;
- Perkins, Andres;
- Matsutani, Takaji;
- Zhong, Zhenyu;
- Dhar, Debanjan;
- Navas-Molina, Jose A;
- Xu, Jun;
- Loomba, Rohit;
- Downes, Michael;
- Yu, Ruth T;
- Evans, Ronald M;
- Dorrestein, Pieter C;
- Knight, Rob;
- Benner, Christopher;
- Anstee, Quentin M;
- Karin, Michael
Published Web Location
https://doi.org/10.1038/nature24302Abstract
IgA+ B cells expressing programmed death ligand 1 (PD-L1) and interleukin 10 accumulate in the inflamed livers of humans and mice with non-alcoholic fatty liver disease where they promote the progression to hepatocellular carcinoma by limiting the local activation of PD-1-expressing CD8+ T cells.
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