Skip to main content
eScholarship
Open Access Publications from the University of California

UC Riverside

UC Riverside Previously Published Works bannerUC Riverside

A role for sex chromosome complement in the female bias in autoimmune disease.

  • Author(s): Smith-Bouvier, Deborah L
  • Divekar, Anagha A
  • Sasidhar, Manda
  • Du, Sienmi
  • Tiwari-Woodruff, Seema K
  • King, Jennifer K
  • Arnold, Arthur P
  • Singh, Ram Raj
  • Voskuhl, Rhonda R
  • et al.
Abstract

Most autoimmune diseases are more common in women than in men. This may be caused by differences in sex hormones, sex chromosomes, or both. In this study, we determined if there was a contribution of sex chromosomes to sex differences in susceptibility to two immunologically distinct disease models, experimental autoimmune encephalomyelitis (EAE) and pristane-induced lupus. Transgenic SJL mice were created to permit a comparison between XX and XY within a common gonadal type. Mice of the XX sex chromosome complement, as compared with XY, demonstrated greater susceptibility to both EAE and lupus. This is the first evidence that the XX sex chromosome complement, as compared with XY, confers greater susceptibility to autoimmune disease.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View