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Open Access Publications from the University of California

Neural mechanisms of response inhibition and impulsivity in 22q11.2 deletion carriers and idiopathic attention deficit hyperactivity disorder.

  • Author(s): Montojo, CA
  • Congdon, E
  • Hwang, L
  • Jalbrzikowski, M
  • Kushan, L
  • Vesagas, TK
  • Jonas, RK
  • Ventura, J
  • Bilder, RM
  • Bearden, CE
  • et al.

•22q11DS offers a compelling model to understand the neural substrates of attentional dysfunction.•First study directly comparing neural function in 22q11DS vs. ADHD patients•22q11DS and ADHD patients show a shared deficit in RI-related activation.•ADHD patients showed greater activity in the middle frontal gyrus than 22q11DS during RI.•Neural activity is inversely correlated with self-reported Cognitive Impulsivity in 22q11DS.

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