Skip to main content
eScholarship
Open Access Publications from the University of California

Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.

  • Author(s): Kilpeläinen, Tuomas O
  • Bentley, Amy R
  • Noordam, Raymond
  • Sung, Yun Ju
  • Schwander, Karen
  • Winkler, Thomas W
  • Jakupović, Hermina
  • Chasman, Daniel I
  • Manning, Alisa
  • Ntalla, Ioanna
  • Aschard, Hugues
  • Brown, Michael R
  • de Las Fuentes, Lisa
  • Franceschini, Nora
  • Guo, Xiuqing
  • Vojinovic, Dina
  • Aslibekyan, Stella
  • Feitosa, Mary F
  • Kho, Minjung
  • Musani, Solomon K
  • Richard, Melissa
  • Wang, Heming
  • Wang, Zhe
  • Bartz, Traci M
  • Bielak, Lawrence F
  • Campbell, Archie
  • Dorajoo, Rajkumar
  • Fisher, Virginia
  • Hartwig, Fernando P
  • Horimoto, Andrea RVR
  • Li, Changwei
  • Lohman, Kurt K
  • Marten, Jonathan
  • Sim, Xueling
  • Smith, Albert V
  • Tajuddin, Salman M
  • Alver, Maris
  • Amini, Marzyeh
  • Boissel, Mathilde
  • Chai, Jin Fang
  • Chen, Xu
  • Divers, Jasmin
  • Evangelou, Evangelos
  • Gao, Chuan
  • Graff, Mariaelisa
  • Harris, Sarah E
  • He, Meian
  • Hsu, Fang-Chi
  • Jackson, Anne U
  • Zhao, Jing Hua
  • Kraja, Aldi T
  • Kühnel, Brigitte
  • Laguzzi, Federica
  • Lyytikäinen, Leo-Pekka
  • Nolte, Ilja M
  • Rauramaa, Rainer
  • Riaz, Muhammad
  • Robino, Antonietta
  • Rueedi, Rico
  • Stringham, Heather M
  • Takeuchi, Fumihiko
  • van der Most, Peter J
  • Varga, Tibor V
  • Verweij, Niek
  • Ware, Erin B
  • Wen, Wanqing
  • Li, Xiaoyin
  • Yanek, Lisa R
  • Amin, Najaf
  • Arnett, Donna K
  • Boerwinkle, Eric
  • Brumat, Marco
  • Cade, Brian
  • Canouil, Mickaël
  • Chen, Yii-Der Ida
  • Concas, Maria Pina
  • Connell, John
  • de Mutsert, Renée
  • de Silva, H Janaka
  • de Vries, Paul S
  • Demirkan, Ayşe
  • Ding, Jingzhong
  • Eaton, Charles B
  • Faul, Jessica D
  • Friedlander, Yechiel
  • Gabriel, Kelley P
  • Ghanbari, Mohsen
  • Giulianini, Franco
  • Gu, Chi Charles
  • Gu, Dongfeng
  • Harris, Tamara B
  • He, Jiang
  • Heikkinen, Sami
  • Heng, Chew-Kiat
  • Hunt, Steven C
  • Ikram, M Arfan
  • Jonas, Jost B
  • Koh, Woon-Puay
  • Komulainen, Pirjo
  • Krieger, Jose E
  • Kritchevsky, Stephen B
  • Kutalik, Zoltán
  • Kuusisto, Johanna
  • Langefeld, Carl D
  • Langenberg, Claudia
  • Launer, Lenore J
  • Leander, Karin
  • Lemaitre, Rozenn N
  • Lewis, Cora E
  • Liang, Jingjing
  • Lifelines Cohort Study
  • Liu, Jianjun
  • Mägi, Reedik
  • Manichaikul, Ani
  • Meitinger, Thomas
  • Metspalu, Andres
  • Milaneschi, Yuri
  • Mohlke, Karen L
  • Mosley, Thomas H
  • Murray, Alison D
  • Nalls, Mike A
  • Nang, Ei-Ei Khaing
  • Nelson, Christopher P
  • Nona, Sotoodehnia
  • Norris, Jill M
  • Nwuba, Chiamaka Vivian
  • O'Connell, Jeff
  • Palmer, Nicholette D
  • Papanicolau, George J
  • Pazoki, Raha
  • Pedersen, Nancy L
  • Peters, Annette
  • Peyser, Patricia A
  • Polasek, Ozren
  • Porteous, David J
  • Poveda, Alaitz
  • Raitakari, Olli T
  • Rich, Stephen S
  • Risch, Neil
  • Robinson, Jennifer G
  • Rose, Lynda M
  • Rudan, Igor
  • Schreiner, Pamela J
  • Scott, Robert A
  • Sidney, Stephen S
  • Sims, Mario
  • Smith, Jennifer A
  • Snieder, Harold
  • Sofer, Tamar
  • Starr, John M
  • Sternfeld, Barbara
  • Strauch, Konstantin
  • Tang, Hua
  • Taylor, Kent D
  • Tsai, Michael Y
  • Tuomilehto, Jaakko
  • Uitterlinden, André G
  • van der Ende, M Yldau
  • van Heemst, Diana
  • Voortman, Trudy
  • Waldenberger, Melanie
  • Wennberg, Patrik
  • Wilson, Gregory
  • Xiang, Yong-Bing
  • Yao, Jie
  • Yu, Caizheng
  • Yuan, Jian-Min
  • Zhao, Wei
  • Zonderman, Alan B
  • Becker, Diane M
  • Boehnke, Michael
  • Bowden, Donald W
  • de Faire, Ulf
  • Deary, Ian J
  • Elliott, Paul
  • Esko, Tõnu
  • Freedman, Barry I
  • Froguel, Philippe
  • Gasparini, Paolo
  • Gieger, Christian
  • Kato, Norihiro
  • Laakso, Markku
  • Lakka, Timo A
  • Lehtimäki, Terho
  • Magnusson, Patrik KE
  • Oldehinkel, Albertine J
  • Penninx, Brenda WJH
  • Samani, Nilesh J
  • Shu, Xiao-Ou
  • van der Harst, Pim
  • Van Vliet-Ostaptchouk, Jana V
  • Vollenweider, Peter
  • Wagenknecht, Lynne E
  • Wang, Ya X
  • Wareham, Nicholas J
  • Weir, David R
  • Wu, Tangchun
  • Zheng, Wei
  • Zhu, Xiaofeng
  • Evans, Michele K
  • Franks, Paul W
  • Gudnason, Vilmundur
  • Hayward, Caroline
  • Horta, Bernardo L
  • Kelly, Tanika N
  • Liu, Yongmei
  • North, Kari E
  • Pereira, Alexandre C
  • Ridker, Paul M
  • Tai, E Shyong
  • van Dam, Rob M
  • Fox, Ervin R
  • Kardia, Sharon LR
  • Liu, Ching-Ti
  • Mook-Kanamori, Dennis O
  • Province, Michael A
  • Redline, Susan
  • van Duijn, Cornelia M
  • Rotter, Jerome I
  • Kooperberg, Charles B
  • Gauderman, W James
  • Psaty, Bruce M
  • Rice, Kenneth
  • Munroe, Patricia B
  • Fornage, Myriam
  • Cupples, L Adrienne
  • Rotimi, Charles N
  • Morrison, Alanna C
  • Rao, Dabeeru C
  • Loos, Ruth JF
  • et al.
Abstract

Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
Current View