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Cytosolic BMAL1 moonlights as a translation factor
- Author(s): Michael, AK
- Asimgil, H
- Partch, CL
- et al.
Published Web Location
https://doi.org/10.1016/j.tibs.2015.07.006Abstract
© 2015. It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.
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