UC Santa Cruz
Cytosolic BMAL1 moonlights as a translation factor
- Author(s): Michael, AK
- Asimgil, H
- Partch, CL
- et al.
Published Web Locationhttps://doi.org/10.1016/j.tibs.2015.07.006
© 2015. It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.
Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.