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Cytosolic BMAL1 moonlights as a translation factor.

  • Author(s): Michael, Alicia K;
  • Asimgil, Hande;
  • Partch, Carrie L
  • et al.
Abstract

It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.

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