UC Santa Cruz
Cytosolic BMAL1 moonlights as a translation factor.
- Author(s): Michael, Alicia K
- Asimgil, Hande
- Partch, Carrie L
- et al.
Published Web Locationhttps://doi.org/10.1016/j.tibs.2015.07.006
It is widely recognized that BMAL1 is an essential subunit of the primary transcription factor that drives rhythmic circadian transcription in the nucleus. In a surprising turn, Lipton et al. now show that BMAL1 rhythmically interacts with translational machinery in the cytosol to stimulate protein synthesis in response to mTOR signaling.