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The molecular mechanism of B cell activation by toll-like receptor protein RP-105.

  • Author(s): Chan, VW;
  • Mecklenbräuker, I;
  • Su, I;
  • Texido, G;
  • Leitges, M;
  • Carsetti, R;
  • Lowell, CA;
  • Rajewsky, K;
  • Miyake, K;
  • Tarakhovsky, A
  • et al.
Abstract

The B cell-specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C beta I/II (PKCbetaI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105-mediated signaling cascade in B cells. We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation.

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