Skip to main content
eScholarship
Open Access Publications from the University of California

Longer leukocyte telomere length in Costa Rica's Nicoya Peninsula: A population-based study

  • Author(s): Rehkopf, DH
  • Dow, WH
  • Rosero-Bixby, L
  • Lin, J
  • Epel, ES
  • Blackburn, EH
  • et al.

Published Web Location

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3819141/
No data is associated with this publication.
Abstract

Studies in humans suggest that leukocyte telomere length may act as a marker of biological aging. We investigated whether individuals in the Nicoya region of Costa Rica, known for exceptional longevity, had longer telomere length than those in other parts of the country. After controlling for age, age squared, rurality, rainy season and gender, the mean leukocyte telomere length in Nicoya was substantially longer (81 base pairs, p. <. 0.05) than in other areas of Costa Rica, providing evidence of a biological pathway to which this notable longevity may be related. This relationship remains unchanged (79 base pairs, p. <. 0.05) after statistically controlling for nineteen potential biological, dietary and social and demographic mediators. Thus the difference in the mean leukocyte telomere length that characterizes this unique region does not appear to be explainable by traditional behavioral and biological risk factors. More detailed examination of mean leukocyte telomere length by age shows that the regional telomere length difference declines at older ages. © 2013 Elsevier Inc.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item