Skip to main content
Affinity-Guided Design of Caveolin‑1 Ligands for Deoligomerization
Published Web Location
http://media.wix.com/ugd/9ecda9_4f3a90d4c723468d9f667019742cda83.pdfNo data is associated with this publication.
Abstract
Caveolin-1 is a target for academic and pharmaceutical research due to its many cellular roles and associated diseases. We report peptide WL47 (1), a small, high-affinity, selective disrupter of caveolin-1 oligomers. Developed and optimized through screening and analysis of synthetic peptide libraries, ligand 1 has 7500-fold improved affinity compared to its T20 parent ligand and an 80% decrease in sequence length. Ligand 1 will permit targeted study of caveolin-1 function.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.