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Cochlear-microphonic and middle-ear pressure changes during nitrous oxide anesthesia in cats.

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The amplitude of cochlear-microphonic responses in cats was attenuated up to 18 dB during both induction and recovery from nitrous oxide anesthesia, with smaller changes (up to 3 dB) occurring during the periods of maintained anesthesia. This response variability was clearly related to alterations of middle-ear pressure and could not be attributed to changes in middle-ear muscle or efferent olivocochlear bundle activities. Middle-ear pressure rose during inhalation of nitrous oxide with periodic abrupt returns to baseline levels during the period of maintained anesthesia; pressure became negative after withdrawal of nitrous oxide. © 1972 Acoustical Society of America

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