High-bandwidth frequency-domain photon migration instrument for clinical use
Published Web Locationhttps://doi.org/10.1117/12.209976
We have developed a high-bandwidth frequency-domain photon migration (FDPM) instrument which capable of noninvasively determining the optical properties of biological tissues in near-real-time. This portable, inexpensive, diode-based instrument is unique in the sense that we employ direct diode laser modulation avalanche photodiode detection. Diffusion models were used to extract the optical properties (absorption and transport scattering coefficients) of tissue-simulating solution from the 300 kHz to 1 GHz photon density wave data.