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Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling

  • Author(s): Shokat, Kevan
  • Weiss, Arthur
  • Tan, YX
  • Manz, BN
  • Freedman, TS
  • Zhang, C
  • Shokat, KM
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3946925?pdf=render
No data is associated with this publication.
Abstract

Signaling via the T cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs). To understand how the kinase Csk, a negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice that express a Csk va

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