Inhibition of the kinase Csk in thymocytes reveals a requirement for actin remodeling in the initiation of full TCR signaling
- Author(s): Shokat, Kevan
- Weiss, Arthur
- Tan, YX
- Manz, BN
- Freedman, TS
- Zhang, C
- Shokat, KM
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC3946925?pdf=render
Signaling via the T cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs). To understand how the kinase Csk, a negative regulator of SFKs, controls the basal state and the initiation of TCR signaling, we generated mice that express a Csk va
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