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[ 11 C]Ascorbic and [ 11 C]dehydroascorbic acid, an endogenous redox pair for sensing reactive oxygen species using positron emission tomography

Published Web Location

https://doi.org/10.1039/c6cc00895j
Abstract

Here we report the radiosynthesis of an endogenous redox pair, [(11)C]ascorbic acid ([(11)C]VitC) and [(11)C]dehydroascorbic acid ([(11)C]DHA), the reduced and oxidized forms of vitamin C, and their application to ROS sensing. These results provide the basis for in vivo detection of ROS using positron emission tomography (PET).

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