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Open Access Publications from the University of California

Role of C-Reactive Protein in Contributing to Increased Cardiovascular Risk in Metabolic Syndrome

  • Author(s): Devaraj, Sridevi
  • Valleggi, Simona
  • Siegel, David
  • Jialal, Ishwarlal
  • et al.

Metabolic syndrome is associated with increased propensity for diabetes and cardiovascular disease. Low-grade inflammation is characteristic of metabolic syndrome. C-reactive protein, the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. This review outlines the role of high-sensitivity C-reactive protein in contributing to increased cardiovascular risk in metabolic syndrome by inducing endothelial cell dysfunction and activating monocytes.

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