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Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

  • Author(s): Weiner, Michael
  • Rajagopalan, P
  • Jahanshad, N
  • Stein, JL
  • Hua, X
  • Madsen, SK
  • Kohannim, O
  • Hibar, DP
  • Toga, AW
  • Jack, CR
  • Saykin, AJ
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3757723?pdf=render
No data is associated with this publication.
Abstract

A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people

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