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Commonfolate gene variant, MTHFR C677T, is associated with brain structure in two independent cohorts of people with mild cognitive impairment

  • Author(s): Weiner, Michael;
  • Rajagopalan, P;
  • Jahanshad, N;
  • Stein, JL;
  • Hua, X;
  • Madsen, SK;
  • Kohannim, O;
  • Hibar, DP;
  • Toga, AW;
  • Jack, CR;
  • Saykin, AJ
  • et al.

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A commonly carried C677T polymorphism in a folate-related gene, MTHFR, is associated with higher plasma homocysteine, a well-known mediator of neuronal damage and brain atrophy. As homocysteine promotes brain atrophy, we set out to discover whether people

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