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Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa
Abstract
Objective
No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison.Method
This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy.Results
Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months.Discussion
This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.