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Differential weight restoration on olanzapine versus fluoxetine in identical twins with anorexia nervosa

  • Author(s): Duvvuri, V
  • Cromley, T
  • Klabunde, M
  • Boutelle, K
  • Kaye, WH
  • et al.

Published Web Location

https://doi.org/10.1002/eat.20917Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Public License
Abstract

Objective: No studies have compared the response to selective serotonin reuptake inhibitors and atypical antipsychotics in anorexia nervosa. This case study examines such a comparison. Method: This report describes a case of 12-year-old identical twins with anorexia nervosa, one of whom was treated with olanzapine and the other with fluoxetine, while undergoing family therapy. Results: Twin A treated with fluoxetine went from 75 to 84.4% ideal body weight, while Twin B treated with olanzapine went from 72 to 99.9% ideal body weight over the course of 9 months. Discussion: This case supports the need for adequately powered, controlled clinical trials to test the efficacy of olanzapine in adolescents presenting with anorexia nervosa. © 2011 by Wiley Periodicals, Inc.

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