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Neuroblastoma Metastases: Leveraging the Avian Neural Crest
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https://doi.org/10.1016/j.ccell.2017.09.012Abstract
Neuroblastoma, an embryonal cancer of neural crest origin, shows metastases frequently at diagnosis. In this issue of Cancer Cell, Delloye-Bourgeois and colleagues demonstrate that neuroblastoma cell lines and patient-derived xenografts engraft and adopt a metastatic program in chick embryos. They identify Sema3C as a candidate switch that regulates metastatic spread.
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