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PKC phosphorylates HEXIM1 and regulates P-TEFb activity

  • Author(s): Peterlin, Boris
  • Fujinaga, K
  • Barboric, M
  • Li, Q
  • Luo, Z
  • Price, DH
  • Peterlin, BM
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3467075?pdf=render
No data is associated with this publication.
Abstract

The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 binds to 7SK snRNA and recruits as well as inactivates P-TEFb

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