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PKC phosphorylates HEXIM1 and regulates P-TEFb activity

  • Author(s): Peterlin, Boris;
  • Fujinaga, K;
  • Barboric, M;
  • Li, Q;
  • Luo, Z;
  • Price, DH;
  • Peterlin, BM
  • et al.

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The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 binds to 7SK snRNA and recruits as well as inactivates P-TEFb

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