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PKC phosphorylates HEXIM1 and regulates P-TEFb activity
- Author(s): Peterlin, Boris;
- Fujinaga, K;
- Barboric, M;
- Li, Q;
- Luo, Z;
- Price, DH;
- Peterlin, BM
- et al.
Published Web Location
http://europepmc.org/articles/PMC3467075?pdf=renderNo data is associated with this publication.
Abstract
The positive transcription elongation factor b (P-TEFb) regulates RNA polymerase II elongation. In cells, P-TEFb partitions between small active and larger inactive states. In the latter, HEXIM1 binds to 7SK snRNA and recruits as well as inactivates P-TEFb
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