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Open Access Publications from the University of California

Field use of N-butylscopolammonium bromide to facilitate thorough ophthalmic examination in horses

  • Author(s): Palmero, J
  • Hollingsworth, S
  • Kass, P
  • Moore, S
  • Pusterla, N
  • et al.

© 2016 Elsevier Ltd. N-butylscopolammonium bromide (NBB), an anticholinergic muscarinic antagonist, was assessed as a mydriatic agent for field examination of equine eyes. Six adult horses were randomly assigned to four treatments with 2 weeks washout between treatments: (1) topical saline/IV saline (negative control); (2) topical tropicamide/IV saline (positive control); (3) topical NBB/IV saline; or (4) topical saline/IV NBB. Horizontal and vertical pupil diameters, temperature, pulse, respiration, pupillary light reflexes (PLRs) and mydriasis sufficient to perform complete fundic examination were recorded. Tropicamide induced mydriasis in all horses. Topical NBB induced mydriasis in one horse, and IV NBB enabled thorough fundic examination in two horses, delayed PLRs without allowing thorough examination in two horses and had no effect in two horses.

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