Skip to main content
Open Access Publications from the University of California


UC San Francisco Previously Published Works bannerUCSF

Ultrasound-guided methylene blue dye injection for parathyroid localization in the reoperative neck.

  • Author(s): Candell, Leah
  • Campbell, Michael J
  • Shen, Wen T
  • Gosnell, Jessica E
  • Clark, Orlo H
  • Duh, Quan-Yang
  • et al.


The goal of this study was to review a single institution's experience using intraoperative ultrasound-guided (ioUSG) methylene blue dye injection for the localization and removal of enlarged parathyroid glands in patients with primary hyperparathyroidism and a history of previous neck surgery.


We performed a retrospective review of nine consecutive patients who underwent reoperative parathyroidectomy using ioUSG methylene blue dye injection.


All patients had successful resolution of their hyperparathyroidism, with at least a 50 % decrease in intraoperative parathyroid hormone level after resection. One patient had transient recurrent laryngeal nerve paresis. There were no permanent recurrent laryngeal nerve injuries or cases of permanent hypoparathyroidism.


Blue dye injection is a safe and effective method of localizing diseased parathyroid glands in the reoperative neck.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item