Skip to main content
Open Access Publications from the University of California

Cold spot mapping inferred from MRI at time of failure predicts biopsy-proven local failure after permanent seed brachytherapy in prostate cancer patients: Implications for focal salvage brachytherapy

  • Author(s): Crehange, G
  • Krishnamurthy, D
  • Cunha, JA
  • Pickett, B
  • Kurhanewicz, J
  • Hsu, IC
  • Gottschalk, AR
  • Shinohara, K
  • Roach, M
  • Pouliot, J
  • et al.

Published Web Location
No data is associated with this publication.

Background and purpose (1) To establish a method to evaluate dosimetry at the time of primary prostate permanent implant (pPPI) using MRI of the shrunken prostate at the time of failure (tf). (2) To compare cold spot mapping with sextant-biopsy mapping at tf. Material and methods Twenty-four patients were referred for biopsy-proven local failure (LF) after pPPI. Multiparametric MRI and combined-sextant biopsy with a central review of the pathology at tfwere systematically performed. A model of the shrinking pattern was defined as a Volumetric Change Factor (VCF) as a function of time from time of pPPI (t0). An isotropic expansion to both prostate volume (PV) and seed position (SP) coordinates determined at tfwas performed using a validated algorithm using the VCF. Results pPPI CT-based evaluation (at 4 weeks) vs. MR-based evaluation: Mean D90% was 145.23 ± 19.16 Gy [100.0-167.5] vs. 85.28 ± 27.36 Gy [39-139] (p = 0.001), respectively. Mean V100% was 91.6 ± 7.9% [70-100%] vs. 73.1 ± 13.8% [55-98%] (p = 0.0006), respectively. Seventy-seven per cent of the pathologically positive sextants were classified as cold. Conclusions Patients with biopsy-proven LF had poorer implantation quality when evaluated by MRI several years after implantation. There is a strong relationship between microscopic involvement at tfand cold spots. © 2013 Elsevier Ireland Ltd. All rights reserved.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item