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From Racemic Alcohols to Enantiopure Amines: Ru-Catalyzed Diastereoselective Amination

Published Web Location

https://doi.org/10.1021/ja5058482
Abstract

A commercially available ruthenium(II) PNP-type pincer catalyst (Ru-Macho) promotes the formation of α-chiral tert-butanesulfinylamines from racemic secondary alcohols and Ellman's chiral tert-butanesulfinamide via a hydrogen borrowing strategy. The formation of α-chiral tert-butanesulfinylamines occurs in yields ranging from 31% to 89% with most examples giving >95:5 dr.

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