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Studies on in vitro models of cellular immunity: The role of T and B cells in the secretion of lymphotoxin

Published Web Location

https://doi.org/10.1016/0008-8749(73)90253-0
Creative Commons 'BY' version 4.0 license
Abstract

When normal murine spleen cells were treated with anti-theta serum and complement, they failed to produce LT or synthesize cellular DNA when stimulated in vitro with PHA. Theta-positive cells were responsible for LT production in spleens removed from X-irradiated and bone marrow- or thymus-reconstituted animals. Finally, spleens from congenitally athymic Nu/Nu mice failed to produce LT when stimulated with pokeweed mitogen or phytohemagglutinin.

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