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CREB regulates excitability and the allocation of memory to subsets of neurons in the amygdala
- Zhou, Yu;
- Won, Jaejoon;
- Karlsson, Mikael Guzman;
- Zhou, Miou;
- Rogerson, Thomas;
- Balaji, Jayaprakash;
- Neve, Rachael;
- Poirazi, Panayiota;
- Silva, Alcino J
Published Web Location
https://doi.org/10.1038/nn.2405Abstract
Silva et al. show that CREB modulates allocation of fear memory to specific cells in the lateral amygdala. Reversibly inactivating a subset of CREB-expressing neurons disrupted memory for tone conditioning. Neurons with higher CREB levels were more excitable than their neighbors and showed larger synaptic efficacy changes following tone conditioning.
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