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Open Access Publications from the University of California

Expression of the TEL-Syk Fusion Protein in Hematopoietic Stem Cells Leads to Rapidly Fatal Myelofibrosis in Mice

  • Author(s): Lowell, Clifford
  • Graham, MT
  • Abram, CL
  • Hu, Y
  • Lowell, CA
  • et al.

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The TEL-Syk fusion protein was isolated from a patient with myelodysplasia with megakaryocyte blasts. Expression of TEL-Syk transforms interleukin-3 (IL-3)-dependent Ba/F3 cells in vitro by deregulating STAT5-mediated signal transduction pathways. In vivo,

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