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Expression of the TEL-Syk Fusion Protein in Hematopoietic Stem Cells Leads to Rapidly Fatal Myelofibrosis in Mice

  • Author(s): Lowell, Clifford
  • Graham, MT
  • Abram, CL
  • Hu, Y
  • Lowell, CA
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3792906?pdf=render
No data is associated with this publication.
Abstract

The TEL-Syk fusion protein was isolated from a patient with myelodysplasia with megakaryocyte blasts. Expression of TEL-Syk transforms interleukin-3 (IL-3)-dependent Ba/F3 cells in vitro by deregulating STAT5-mediated signal transduction pathways. In vivo,

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