Folate status of gut microbiome affects Caenorhabditis elegans lifespan
- Author(s): Nguyen, Theresa PT
- Clarke, Catherine F
- et al.
Published Web Locationhttp://dx.doi.org/10.1186/1741-7007-10-66
Abstract In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation. See research article http://www.http://www.biomedcentral.com/1741-7007/10/67