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Open Access Publications from the University of California

Folate status of gut microbiome affects Caenorhabditis elegans lifespan

  • Author(s): Nguyen, Theresa PT
  • Clarke, Catherine F
  • et al.

Abstract In a paper in BMC Biology Virk et al. show that Caenorhabditis elegans lifespan is extended in response to a diet of folate-deficient Escherichia coli. The deficiencies in folate biosynthesis were due to an aroD mutation, or treatment of E. coli with sulfa drugs, which are mimics of the folate precursor para-aminobenzoic acid. This study suggests that pharmacological manipulation of the gut microbiome folate status may be a viable approach to slow animal aging, and raises questions about folate supplementation. See research article http://www.

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