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A common Greenlandic TBC1D4 variant confers muscle insulin resistance and type 2 diabetes
Published Web Location
https://doi.org/10.1038/nature13425Abstract
An association mapping study of type-2-diabetes-related quantitative traits in the Greenlandic population identified a common variant in TBC1D4 that increases plasma glucose levels and serum insulin levels after an oral glucose load and type 2 diabetes risk, with effect sizes several times larger than any previous findings of large-scale genome-wide association studies for these traits.
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