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Tetramethylenedisulfotetramine

  • Author(s): Banks, CN
  • Yang, D
  • Lein, PJ
  • Rogawski, MA
  • et al.
Abstract

Tetramethylenedisulfotetramine (CAS 80-12-6), commonly referred to as TETS, was first synthesized in 1933 as a condensation product of sulfamide and formaldehyde. TETS was subsequently used as a rodenticide until banned worldwide in 1991. TETS is, however, still available illegally, primarily in rural China, and is responsible for accidental and intentional poisonings that cause a significant number of human deaths annually. TETS induces convulsive seizures mediated by antagonism of γ-amino-butyric acid (GABA)-mediated chloride channels. There are no known antidotes for TETS poisoning, and in cases of severe TETS intoxication that progress to status epilepticus, prognosis is poor even with aggressive anti-convulsant treatment.

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